Spindle Cell Lipomas: A Report of Two Cases, One with Multiple Lesions

Darius R. Mehregan, MD, David A. Mehregan, MD, Amir H. Mehregan, MD,
Michael A Dorman, MD, and Edwin Cohen, MD

BACKGROUND: Spindle cell lipoma is an unusual and histologically distinctive form of lipoma occurring primarily in older individuals.

OBJECTIVE: The dermatologic surgeon and pathologist should be familiar with this variant of lipoma. METHODS: We are reporting two cases of spindle cell lipomas with the results of histologic examination with special stains and immunohistochemical studies.

RESULTS: The neoplasms consisted of lobulated masses of mature adipose tissue with areas of spindle cell proliferation. There was strong positive staining with antibodies for vimentin within the areas of spindle cell proliferation. One of the cases is unusual in that multiple lesions are occurring in a young patient.

CONCLUSION: Recognition of the histologic pattern is important in distinguishing the benign spindle cell lipoma from the malignant liposarcoma.

Dermatol Surg 1995; 21: 796-8