Giant Cerebriform and Disseminated Molluscum Contagiosum in Atopic Dermatitis

Melanie K. Kuechle, MD, Darius R. Mehregan, MD, Randall K. Roenigk, MD, and Sigfrid A. Muller, MD
Patients with atopic dermatitis have an increased susceptibility to certain viral infections, particularly those caused by Herpes simplex virus, human papilloma virus, and molluscum contagiosum. We describe two patients with atopic dermatitis who had unusually widespread and large lesions of molluscum contagiosum. One patient had a clonal proliferation of a T-cell population with an aberrant phenotype, and the other had persistent eosinophilia with marked elevation of IgE. The unusual clinical presentations of molluscum contagiosum and its association with altered immunity and atopic dermatitis are discussed.

Key words: atopic dermatitis, clonal T-cells, eosinophilia, increased IgE, molluscum contagiosum.

Eur J Dermatol 1996; 6: 274-7