Cutaneous Malakoplakia: A Report of Two Cases with the use of Anti-BCG for the Detection for Micro-Organisms

Darius R. Mehregan, M.D., Amir H. Mehregan, M.D., and David A. Mehregan, M.D., Monroe, Michigan
Malakoplakia is an uncommon granulomatous infectious disease that is found primarily in the genito-urinary tract, but may rarely involve the skin. Histologic findings are marked by the presence of foamy macrophages containing basophilic concentric spherules, the Michaelis-Gutman bodies. Micro-organisms are not readily identifiable. Immunostaining with polyclonal anti-mycobacterium bovis (BCG) has been described as a method of identifying bacterial and fungal organisms in situations where organisms may be sparse. We report two cases of cutaneous malakoplakia with demonstration of organisms by immunostaining with anti-BCG antibodies.

JAAD; 43:351-4